Hormonal Effects on Thymidine Kinase Activity in Normal Rat Adrenal and in Hormone-dependent Adrenal Carcinoma1
نویسندگان
چکیده
In estrogen-dependent rat adrenocortical carcinomas, thymidine kinase activity decreased during tumor regression following removal of estrogen from the host. The change in the kinase activity could be prevented by estrogen administration but not by the administration of growth hormone or adrenocorticotropic hormone. The alterations in kinase activity were not due to changes in the activity of competing enzymes. Studies of the normal rat adrenal showed that the kinase activity of this tissue is independent of the estrogen supply of the host animal.
منابع مشابه
Hormonal effects on thymidine kinase activity in normal rat adrenal and in hormone-dependent adrenal carcinoma.
In estrogen-dependent rat adrenocortical carcinomas, thymidine kinase activity decreased during tumor regression following removal of estrogen from the host. The change in the kinase activity could be prevented by estrogen administration but not by the administration of growth hormone or adrenocorticotropic hormone. The alterations in kinase activity were not due to changes in the activity of c...
متن کاملHormonal effects on thymidine kinase and thymidylate kinase activity of estrogen-dependent tumors in the rat.
In estrogen-induced, estrogen-dependent, mammary and adrenocorlical carcinomas, the specific activities of t lie tliymidine kinasc and thymidylate kinase decreased significantly within 2 to 4 days after removal of the source of estrogen of the host. After 7 days, these changes were even more marked in the adrenal tumors. Similar changes were not observed in the activity of these enzymes in auto...
متن کاملExposure to cell phone radiofrequency changes corticotrophin hormone levels and histology of the brain and adrenal glands in male Wistar rat
Objective(s): Nowadays, the electromagnetic field-emitting devices are used routinely in our lives. Controversial reports exist concerning the effects of mobile radiofrequency (RF) on different parts of the body, especially stress hormones. The main goal of the present work was to study the long-term effects of mobile RF900 MHz exposure with special focus on the adrenal gland pathophysiology an...
متن کاملEffects of Type 1 and Type 2 Diabetes on Micro-Anatomical Changes of Adrenal Gland in Male Wistar Rats
Background & Aims: Changing the hormonal output of endocrine glands, diabetes leads to the occurrence of secondary metabolic disorders. Neuropathy, on the other hand, is the most common neurological complication of diabetes which affects the neuroendocrine system, in addition to peripheral and autonomic nervous system, contributing to exacerbation of disease severity. In this line, the present ...
متن کاملEffects of Noise Exposure on the Volume of Adrenal Gland and Serum Levels of Cortisol in Rat
Background: Noise pollution is considered as a stressful factor in every day’s life of the industrial world. The present study was designed to investigate the probable effects of different time exposure of noise stress on histomorphometric changes of adrenal gland, plasma cortisol and body weight of the rat. Methods: Sixty adult male Wistar rats were divided into two series of short time noise ...
متن کامل